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Zabofloxacin

Phase 3

Chronic Obstructive Pulmonary Disease | Small molecule | Other |Co-Diagnostics, Inc.|Last Updated: Oct 13, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment345
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01658020A Study to Evaluate Efficacy and Safety Profile of Zabofloxacin Tablet 400mg and Moxifloxacin Tablet 400mgPHASE3 COMPLETED 345Aug 1, 2012Aug 1, 2014Oct 13, 20141 South Korea
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Study Endpoints
Primary Endpoints
Clinical Response in the Clinical Populations
10days

Clinical response corresponding clinical cure at Test of Cure visit. Based on the clinical outcomes, the results of assessment were classified into Clinical Cure, Clinical Failure, Relapse and Indeterminate.

Secondary Endpoints
Clinical Response in the Clinical Population
36days
Clinical Cure Rate in the Microbiological Per Protocol(PP) Population
10days
Microbiological Response Rate
10days
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Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
DW224EXPERIMENTALZabofloxacin 367mg tablet P.O. once daily for 5days and then Placebo P.O. once daily for 2days
AveloxACTIVE_COMPARATORMoxifloxacin 400mg tablet P.O. once daily for 7days
Interventions
NameTypeDescription
ZabofloxacinDRUGZabofloxacin 367mg tablet P.O. once daily for 5days and then Placebo P.O. once daily for 2days
MoxifloxacinDRUGMoxifloxacin 400mg tablet P.O. once daily for 7days
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Eligibility Criteria
Age Range40 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Adult male or female same or older than age of 40 * Severity of acute exacerbation of Chronic obstructive pulmonary disease(COPD) must suit oral administration treatment * Diagnosed as COPD before receiving written informed consent and outcome measure of spirometry testing con...

Countries:South Korea
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