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Motilitone

Phase 2

Dyspepsia | Small molecule | Other |Co-Diagnostics, Inc.|Last Updated: May 21, 2019

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment45
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02365701Study of Motilitone to Treat Functional DyspepsiaPHASE2 COMPLETED 45Jun 1, 2015Feb 1, 2018May 21, 20191 United States
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Study Endpoints
Primary Endpoints
Change in maximum tolerated volume by nutrient drink test
week -2, week 4
Change in aggregate symptom score by nutrient drink test
week -2, week 4
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Motilitone 30mgEXPERIMENTALMotilitone will be administered in tablet form, 3 times daily to subjects randomized to this arm of the study. Subjects will be expected to take this medication for 4 weeks.
PlaceboPLACEBO_COMPARATORPlacebo (same formulation as Motilitone but without the active ingredients) will be administered in tablet form, 3 times daily to subjects randomized to this arm of the study. Subjects will be expected to take this tablet for 4 weeks.
Interventions
NameTypeDescription
Motilitone 30mgDRUG30mg of Motilitone in tablet form, to be taken 3 times daily for 4 weeks
PlaceboDRUGPlacebo, in tablet form, to be taken 3 times daily for 4 weeks. The placebo is the same formulation as Motilitone except that it does not contain the active pharmaceutical ingredient.
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * (1) Subject fulfilling Rome III criteria for Functional Dyspepsia: They must have one or more of the following: 1. Bothersome postprandial fullness 2. Early satiation 3. Epigastric pain 4. Epigastric burning AND No evidence of structural disease at upper endoscopy wit...

Countries:United States
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