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IL-YANG FLU Vaccine

Phase 1

Healthy | Monoclonal antibody | Other |Co-Diagnostics, Inc.|Last Updated: Apr 10, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment44
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02111070Immunogenicity and Safety Study of Inactivated Split Influenza Vaccine' in Healthy Korean Male SubjectsPHASE1 COMPLETED 44Sep 1, 2012Oct 1, 2012Apr 10, 20141 South Korea
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Study Endpoints
Primary Endpoints
Solicited local & general AE, Unsolicited AE
up to Day28(+7)

Solicited local reaction: pain, tenderness, redness, swelling Solicited general reactions: fever, nausea/vomiting, diarrhea, headache, fatigue, myalgia

Percentage of subjects achieving seroprotection for HI antibody after administration of the study vaccine
Day28(+7)

Seroprotection: HI antibody titer ≥ 1:40 28 days after the administration of the study vaccine

Secondary Endpoints
GMT of HI antibody titer before vaccination and after vaccination
Day28(+7)
Percentage of subjects with a pre-vaccination (Day 0) HI antibody titer < 1:40, and a minimum four-fold rise in post-vaccination (vaccination + 28 days) HI antibody titer
Day28(+7)
Vital signs measurements, physical examination findings, ECG results, and laboratory measurements (hematology, biochemistry and urinalysis)
Day28(+7)
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposePREVENTION
Treatment Arms
ArmTypeDescription
ILYANG Inactivated split influenza vaccineEXPERIMENTALIL-YANG FLU Vaccine Vial INJ 0.5mL by intramuscular injection
Interventions
NameTypeDescription
IL-YANG FLU VaccineBIOLOGICAL0.5mL
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Eligibility Criteria
Age Range20 Years — 55 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy males between 20 and 55 years of age at screening * Body weight of ≥ 55kg and within ±20% of ideal body weight (ideal body weight = (height cm - 100) X 0.9) at screening * Subjects with no congenital or chronic disease who were considered suitable for the study after s...

Countries:South Korea
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