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IBI306 Q4W

Phase 3

Hypercholesterolemia | Small molecule | Metabolic |Co-Diagnostics, Inc.|Last Updated: Apr 11, 2022

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment804
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT04289285Safety and Efficacy of IBI306 in Chinese Subjects With Non-familial HypercholesterolemiaPHASE3 COMPLETED 804Apr 29, 2020Feb 9, 2022Apr 11, 20221 China
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Study Endpoints
Primary Endpoints
Mean percent change from baseline in low-density lipoprotein cholesterol (LDL-C) at week 48
Week 48
Secondary Endpoints
The percent of subjects with LDL-C reduction no less than 50% from baseline
Week 48
The percent of subjects with LDL-C<70mg/dL(1.8 mmol/L)
Week 48
The percent change in Lp(a),ApoB, non-HDL-c, ApoB/ApoA1 from baseline
Week 48
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
IBI306 450mg SC Q4WEXPERIMENTAL -
Placebo SC Q4WPLACEBO_COMPARATOR -
IBI306 600mg SC Q6WEXPERIMENTAL -
Placebo SC Q6WPLACEBO_COMPARATOR -
Interventions
NameTypeDescription
IBI306 450mg SC Q4WDRUGSubjects will receive IBI306 450mg every 4 weeks subcutaneously.
Placebo SC Q4WDRUGSubjects will receive placebo every 4 weeks subcutaneously.
IBI306 600mg SC Q6WDRUGSubjects will receive IBI306 600mg every 6 weeks subcutaneously.
Placebo SC Q6WOTHERSubjects will receive placebo every 6 weeks subcutaneously.
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Eligibility Criteria
Age Range18 Years — 75 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion criteria: 1. Males and females ≥ 18 to ≤ 75 years of age 2. Diagnosis of hypercholesterolemia 3. LDL cholesterol ≥ 70 mg/dl (1.8mmol/L) 4. Very high or high cardiovascular risk 5. TG≤500 mg/dL(5.64 mmol/L) Exclusion criteria: 1. Diagnosis of HoFH or HeFH 2. Uncontrolled hypertension 3. ...

Countries:China
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