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FYU-981

Phase 1

Healthy | Small molecule | Other |Co-Diagnostics, Inc.|Last Updated: Dec 12, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedCONTROLLED
Total Trials1
Total Enrollment12
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03350373Clinical Pharmacology of FYU-981 (Final Formulation)PHASE1 COMPLETED 12Nov 6, 2017Nov 29, 2017Dec 12, 20171 Japan
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Study Endpoints
Primary Endpoints
Pharmacokinetics (Cmax: Maximum plasma concentration)
48 hours
Pharmacokinetics (Tmax: Time to reach the peak plasma concentration)
48 hours
Pharmacokinetics
48 hours

T1/2: Elimination half-life of plasma concentration

Pharmacokinetics (AUC: Area under the plasma concentration-time curve)
48 hours
Pharmacokinetics (CLtot/F: Total clearance/Fraction of dose absorbed)
48 hours
Pharmacokinetics (kel: Elimination rate constant)
48 hours
Pharmacokinetics (Vd/F: Distribution volume/Fraction of dose absorbed)
48 hours
Pharmacokinetics (MRT: Mean residence time)
48 hours
Safety (Incidence of treatment-emergent adverse events)
13 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeBASIC_SCIENCE
Treatment Arms
ArmTypeDescription
Fasted dosing followed by fed dosingEXPERIMENTALDosing of FYU-981 in the fasted state followed by fed dosing
Fed dosing followed by fasted dosingEXPERIMENTALDosing of FYU-981 in the fed state followed by fasted dosing
Interventions
NameTypeDescription
FYU-981DRUGSingle administration of FYU-981 under Fasted and fed conditions in the morning.
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Eligibility Criteria
Age Range20 Years — 35 Years
SexMALE
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Japanese healthy adult subjects * Body mass index: \>=18.5 and \<25.0 Exclusion Criteria: * Subjects with any disease or any history of diseases that might be unsuitable for participation in the clinical study

Countries:Japan
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