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Choline

Phase 1

Healthy Male | Small molecule | Other |Co-Diagnostics, Inc.|Last Updated: Mar 24, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment24
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02395926To Evaluate Safety and the Pharmacokinetic Characteristics After Oral Administration of HT-003 Compared With Choline Alfoscerate Capsule in Healthy Adult Male VolunteersPHASE1 COMPLETED 24Oct 1, 2013Dec 1, 2013Mar 24, 2015 -
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Study Endpoints
Primary Endpoints
Cmax
in 24hr after administration
AUClast
in 24hr after administration
Secondary Endpoints
baseline-corrected Cmax
in 24hr after administration and before administration
baseline-corrected AUClast
in 24hr after administration and before administration
Tmax
in 24hr after administration and before administration
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
RACTIVE_COMPARATORGliatilin soft capsule 400mg, administration 3 times per 1day 8:00 a.m., 14:00, 20:00
T1EXPERIMENTALHT-003 600mg, administration 2 times per 1 day 8:00 a.m., 20:00
T2EXPERIMENTALHT-003 600mg\*2tab, administration 1 times per 1 day 8:00 a.m.
Interventions
NameTypeDescription
Choline CR 600mgDRUGHT-003 600mg, administration 2 times per 1 day 8:00 a.m., 20:00
Gliatilin 400mgDRUGGliatilin soft capsule 400mg, administration 3 times per 1day 8:00 a.m., 14:00, 20:00
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Eligibility Criteria
Age Range20 Years — 55 Years
SexMALE
Healthy VolunteersYes

Inclusion Criteria: 1. Healthy male subjects between the ages of 20 and 55 years, inclusive 2. BMI\>=19kg/m2, \<=27kg/m2 \*body mass index (kg/m2) = weight (kg)/ \[(height (m)2) 3. Voluntary written consent by the parties that the ability and willingness to participate during the entire period ...

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