Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT02728349 | Tolerance and Pharmacokinetic Study of Chlorogenic Acid to Advanced Glioblastoma | PHASE1 | COMPLETED | 26 | — | — | Apr 12, 2016 | Sep 13, 2017 | Nov 1, 2018 | 1 | China |
| Arm | Type | Description |
|---|---|---|
| Chlorgenic acid, Treatment, powder | EXPERIMENTAL | Chlorogenic acid for injection(30mg/bottle) is white or off-white freeze-dried lump or powder,it can be easily dissolved in water, which solubility is 20%. |
| Name | Type | Description |
|---|---|---|
| Chlorogenic acid | DRUG | Chlorogenic acid for injection is polyphenols, micromolecular and un-endogenous substance. It might play the role of cancer treatment via balancing tumor micro-environmental immune status according to the stability and rationality of immunodeficiency and endogenous immune material expression around the tumor. Chlorogenic acid for injection is made from chlorogenic acid (purity≥98%) which is extracted from folium cortex eucommiae.Chlorogenic acid and its preparations have not been reported as chemical drug and marketed around the world. |
Inclusion Criteria: 1. Patients with pathologic or/and FNAC confirmation of advanced glioblastoma(WHO,III-IV grade) but without effective treatment or with treatment failure; 2. Between 18 and 65 years of age, KPS≥40; 3. According to RANO(2010), the parents will be eligible if one of the following ...