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BIIB023 - low dose Dose

Phase 1

Healthy Volunteers | Small molecule | Other |Biogen Inc.|Last Updated: Sep 16, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindCONTROLLEDBiomarker
Total Trials1
Total Enrollment48
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01407406Phase 1 Study to Evaluate the PK, Safety, Tolerability of BIIB023 in Chinese, Japanese, and Caucasian Healthy VolunteersPHASE1 COMPLETED 48Sep 1, 2011Feb 1, 2012Sep 16, 20132 Australia, China
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Study Endpoints
Primary Endpoints
AUC of BIIB023
Participants will be followed for the duration of a study; an expected 71 days
Cmax of BIIB023
Participants will be followed for the duration of a study; an expected 71 days
Tmax of BIIIB023
Participants will be followed for the duration of a study; an expected 71 days
Half-life of BIIB023
Participants will be followed for the duration of a study; an expected 71 days
Volume of distribution of BIIB023
Participants will be followed for the duration of a study; an expected 71 days
Clearance of BIIB023
Participants will be followed for the duration of a study; an expected 71 days
Secondary Endpoints
Number of patients with Adverse Events as a measure of safety and tolerability
Participants will be followed for the duration of a study; an expected 71 days
Number of patients with Serious Adverse Events as a measure of safety and tolerability
Participants will be followed for the duration of a study; an expected 71 days
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeBASIC_SCIENCE
Treatment Arms
ArmTypeDescription
Chinese Subjects - low dose BIIB023 IVEXPERIMENTAL -
Chinese Subjects - high dose BIIB023 IVEXPERIMENTAL -
Japanese Subjects - low dose BIIB023 IVEXPERIMENTAL -
Japanese Subjects - high dose BIIB023 IVEXPERIMENTAL -
Causasian Subjects - low dose BIIB023 IVEXPERIMENTAL -
Caucasian Subjects - high dose BIIB023 IVEXPERIMENTAL -
Interventions
NameTypeDescription
BIIB023 - low dose IV DoseDRUG -
BIIB023 - high dose IV DoseDRUG -
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Eligibility Criteria
Age Range18 Years — 55 Years
SexALL
Healthy VolunteersYes
Study Sites2

Inclusion Criteria: * Must have the ability to understand the purpose and risks of the study \& provide signed \& dated informed consent. * Chinese, Japanese or Caucasian subjects * Subjects of childbearing potential must practice effective contraception during the study and 3 months after their la...

Countries:AustraliaChina
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