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ASV AGEN2017 + QS-21 Stimulon adjuvant

Phase 1

Solid Tumor, Adult | Monoclonal antibody | Oncology |Agenus Inc.|Last Updated: Dec 2, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment3
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT03673020Phase 1a Study to Evaluate Immunogenicity of ASV®PHASE1 COMPLETED 3May 16, 2019Feb 3, 2021Dec 2, 20211 United States
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Study Endpoints
Primary Endpoints
Incidence of Treatment-Emergence Adverse Events (Safety and Tolerability)
1 Year

Assessed by monitoring the frequency, duration, and severity of drug-related AEs by completing physical examinations and clinical evaluations; evaluating changes in vital signs; and laboratory blood and urine sample evaluations.

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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
ASV® AGEN2017EXPERIMENTALASV® AGEN2017 + QS-21 Stimulon® Adjuvant Vaccine
Interventions
NameTypeDescription
ASV® AGEN2017 + QS-21 Stimulon® adjuvantBIOLOGICALNeoantigen Vaccine
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: 1. Signed, written informed consent. 2. Age ≥18 years. 3. Diagnosis of solid cancer that has been completely resected, NED, and eligible for observation only as SOC yet remain at risk of relapse per Investigator discretion. These include subjects diagnosed with malignant melanom...

Countries:United States
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