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Depakote /Depakote Sprinkle

Phase 2

Pediatric Epilepsy | Small molecule | Neurology |Abbott Laboratories|Last Updated: Mar 28, 2008

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
CONTROLLED
Total Trials1
Total Enrollment16
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00646711Pediatric Switch Study for Children and Adolescent Patients With EpilepsyPHASE2 COMPLETED 16Feb 1, 2003Dec 1, 2003Mar 28, 20081 United States
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Study Endpoints
Primary Endpoints
Number of seizures
2 weeks
Number of Adverse Events
2 weeks
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Sequence Group IEXPERIMENTALDepakote Delayed Release/Depakote Sprinkle
Sequence Group IIEXPERIMENTALDepakote ER
Interventions
NameTypeDescription
Depakote Delayed-Release/Depakote SprinkleDRUGAdministered according to the subject's usual regimen.
Depakote ERDRUGDose converted to 8-20% higher than Depakote DR or Depakote Sprinkle.
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Eligibility Criteria
Age Range6 Years — 17 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Male or female patient with a clinical diagnosis of epilepsy considered stable by the investigator. * Must be in good physical health, on the same dose of all medications, including Depakote and other AEDs, for 2 week period prior to randomization. * Minimum body weight of 37 ...

Countries:United States
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