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ABT-510 - Thrombospondin-1 mimetic

Phase 2

Sarcoma, Soft Tissue | Small molecule | Oncology |Abbott Laboratories|Last Updated: Nov 29, 2007

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedUNCONTROLLEDBiomarker
Total Trials1
Total Enrollment88
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00061659Study Evaluating the Safety and Efficacy of ABT-510 in Subjects With Locally Advanced or Metastatic Soft Tissue SarcomaPHASE2 COMPLETED 88May 1, 2003Apr 1, 2006Nov 29, 20075 United States
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Study Endpoints
Primary Endpoints
Progression free survival
One year
Secondary Endpoints
Response rate
One year
Overall survival
One year
Performance status
One year
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Interventions
NameTypeDescription
ABT-510 - Thrombospondin-1 mimeticDRUG -
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites5

Inclusion Criteria A subject will be eligible for study participation if all of the following criteria are met: * The subject is at least 18 years of age. * The subject has histologically confirmed high grade locally advanced or metastatic soft tissue sarcoma (excluding Ewings sarcoma and chondros...

Countries:United States
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